Nature-inspired enhancement of enzyme performance by confinement in nanopores

Inspired by the nano-confinement effects induced by chaperones and other biological nanopores on biological guest molecules, we design and synthesize optimized nanoporous materials as hosts for enzymes, for catalytic or therapeutic applications. These materials are designed with ideal geometrical and chemical surface properties that impart aspects of the desired force balancing witnessed in biological systems.

Researchers: Michele Lynch and Justin Siefker.

KEY PUBLICATIONS

  1. J. Siefker, P. Karande, and M.-O Coppens,
    "Packaging biological cargoes in mesoporous materials: opportunities for drug delivery"
    ,
    Exp. Opin. Drug Deliv., 2014, 11, 1781.
    [Link]
  2. L.-C. Sang, A. Vinu, and M.-O. Coppens,
    "General Description of the Adsorption of Proteins at Their Iso-electric Point in Nanoporous Materials"
    , Langmuir, 2011, 27(22), 13828.
    [Link]
  3. L.-C. Sang, A. Vinu, and M.-O. Coppens,
    "Ordered mesoporous carbon with tunable, unusually large pore size and well-controlled particle morphology",
    J. Mater. Chem., 2011, 21, 7410.
    [Link]
  4. L.-C. Sang and M.-O. Coppens,
    "Effects of surface curvature and surface chemistry on the structure and function of proteins adsorbed in nanopores",
    Phys. Chem. Chem. Phys., 2011, 13, 6689. (Invited)
    [Link]
Nature-inspired enhancement of enzyme performance by confinement in nanopores