Cancer Immunotherapy paper appears in Trends in Biotechnology
29 May 2020
A new Opinion piece on "Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity" has been published by Cell Press Trends in Biotechnology. The paper was written by our recent PhD graduate Matthew Chin, in collaboration with CNIE Director Marc-Olivier Coppens, Richard Day (UCL) and Eileen Gentleman (KCL).
Advocating an integrated "complex systems" approach and departing from reductionist thinking, the paper sets out to tackle cancer by adoptive T cell therapy. Nature is replete with complex (eco-)systems that underpin resilience and adaptability and here we see the potential for a nature-inspired approach that combines insights from mechanobiology, systems biology, process intensification, and distributed manufacturing via on-demand networks, similar to the organisation of biological networks, for point-of-care therapy. This paper summarises recent thoughts on systems engineering and health at the CNIE.
The paper can be read by clicking on this link.